As an emerging molecular imaging modality, cone-beam X-ray luminescence computed tomography (CB-XLCT) uses X-ray-excitable probes to produce near-infrared (NIR) luminescence and then reconstructs three-dimensional (3D) distribution of the probes from surface measurements. A proper photon-transportation model is critical to accuracy of XLCT. Here, we presented a systematic comparison between the common-used Monte Carlo model and simplified spherical harmonics (SPN). The performance of the two methods was evaluated over several main spectrums using a known XLCT material. We designed both a global measurement based on the cosine similarity and a locally-averaged relative error, to quantitatively assess these methods. The results show that the SP3 could reach a good balance between the modeling accuracy and computational e±ciency for all of the tested emission spectrums. Besides, the SP1 (which is equivalent to the diffusion equation (DE)) can be a reasonable alternative model for emission wavelength over 692 nm. In vivo experiment further demonstrates the reconstruction performance of the SP3 and DE. This study would provide a valuable guidance for modeling the photon-transportation in CB-XLCT.

采用光束整形的方法, 研制出高效率单阵列光纤耦合半导体激光模块。将波长为976 nm连续工作的标准半导体激光阵列, 经过快轴准直, 阶梯镜组进行快慢轴光束旋转, 慢轴准直, 以及耦合透镜聚焦, 耦合入芯径300 μm, 数值孔径0.22的光纤。测量结果显示: 光纤的出光功率最大可达到63 W, 对应的亮度为1.2 MW/cm2·sr, 光纤耦合效率大于90%。上述结果为进一步实现多个阵列的耦合, 研制数百瓦量级的高效率半导体激光器光纤耦合模块奠定了基础。